Wegovy (oral 25mg) vs Foundayo (orforglipron)
Side-by-side comparison based on OASIS-4 and ATTAIN-1 phase 3 trial data plus April 2026 pricing.
Wegovy (oral 25mg)
semaglutide (tablet)
Peak weight loss13.6%
TrialOASIS-4
Administrationoral
FDA statusweight-loss
List price$1,349/mo
Foundayo (orforglipron)
Higher efficacyorforglipron (tablet)
Peak weight loss14.7%
TrialATTAIN-1
Administrationoral
FDA statuspending
List price$1,099/mo
Weight loss comparison (220 lbs starting weight)
% of body weight lost over 18 months, modeled from phase 3 trial data
Monthly cost by payment channel
| Channel | Wegovy (oral 25mg) | Foundayo (orforglipron) | Difference |
|---|---|---|---|
| Covered by insurance ($25–150 copay) | $63 | $63 | $0 (Foundayo (orforglipron) cheaper) |
| Manufacturer self-pay (LillyDirect / NovoCare) | $499 | $499 | $0 (Foundayo (orforglipron) cheaper) |
| Telehealth — brand name (Hims, Ro, Found) | $449 | — | — |
| Cash retail (full list price) | $1,349 | $1,099 | $250 (Foundayo (orforglipron) cheaper) |
Wegovy (oral 25mg) pros and cons
Pros
- ✓ No injections — daily oral pill
- ✓ Same molecule as Wegovy injection
- ✓ 13.6% average weight loss in OASIS-4
- ✓ Easier to skip a dose without long-acting tail
Cons
- ✗ Strict fasting requirements before/after dose
- ✗ Slightly lower weight loss than injection (13.6% vs 14.9%)
- ✗ Daily dosing may hurt adherence vs weekly injection
- ✗ Newer drug — fewer real-world data points
Foundayo (orforglipron) pros and cons
Pros
- ✓ Daily pill with NO fasting requirement (advantage over oral Wegovy)
- ✓ Non-peptide small molecule — easier manufacturing/scale
- ✓ 14.7% average weight loss in ATTAIN-1
- ✓ Likely to be lower-priced than peptide injections at scale
Cons
- ✗ Pending FDA approval (expected mid-2026)
- ✗ Less long-term safety data than older GLP-1s
- ✗ Daily adherence required
Common side effects
Wegovy (oral 25mg)
- • Nausea
- • Diarrhea
- • Constipation
- • Vomiting
Foundayo (orforglipron)
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
Which should you choose: Wegovy (oral 25mg) or Foundayo (orforglipron)?
Choose Wegovy (oral 25mg) if: you want a drug FDA-approved specifically for weight loss.
Choose Foundayo (orforglipron) if: you want maximum weight loss (14.7% vs 13.6%); cash-pay cost matters most to you.
Final decisions should always be made with a licensed prescriber. This is educational content only.
Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.