Foundayo (orforglipron) (orforglipron (tablet))
Lilly's oral GLP-1, FDA approval expected mid-2026. First-in-class non-peptide oral. Manufactured by Eli Lilly. FDA-approved status: pending.
Peak weight loss
14.7%
Trial
ATTAIN-1
Time to peak
72 wks
List price
$1,099/mo
Foundayo (orforglipron) pricing across every channel
Manufacturer direct prices (LillyDirect, NovoCare) are usually cheapest. Updated April 2026.
| Drug | Insurance | Mfr direct | Telehealth (brand) | Telehealth (compd) | Cash retail | Get it |
|---|---|---|---|---|---|---|
| Foundayo (orforglipron) 14.7% weight loss | $63 cheapest | $499 | — | — | $1,099 | N/A |
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Foundayo (orforglipron) cost in 2026
| Payment channel | Monthly | 12 months |
|---|---|---|
| Covered by insurance ($25–150 copay) | $63 | $756 |
| Manufacturer self-pay (LillyDirect / NovoCare) | $499 | $5,988 |
| Telehealth — brand name (Hims, Ro, Found) | Not available | — |
| Telehealth — compounded (limited post-FDA crackdown) | Not available | — |
| Cash retail (full list price) | $1,099 | $13,188 |
Dosing
Once-daily oral tablet. No fasting requirement (small-molecule, not peptide).
What to expect on Foundayo (orforglipron)
For someone starting at 220 lbs on Foundayo (orforglipron) for 12 months, the projection is:
Expected loss at 12 mo
27 lbs
Final weight
193 lbs
Cost / lb lost
$488
Modeled from ATTAIN-1 phase 3 data. Adjust for your own weight on the full calculator.
✓ Pros
- Daily pill with NO fasting requirement (advantage over oral Wegovy)
- Non-peptide small molecule — easier manufacturing/scale
- 14.7% average weight loss in ATTAIN-1
- Likely to be lower-priced than peptide injections at scale
✗ Cons
- Pending FDA approval (expected mid-2026)
- Less long-term safety data than older GLP-1s
- Daily adherence required
Common side effects
Most-reported in ATTAIN-1. Side effects are typically worst during dose escalation and improve over time.
NauseaDiarrheaVomitingConstipation
→ Full Foundayo (orforglipron) side effects guide (timing, severity, when to call)Compare Foundayo (orforglipron) to other GLP-1s
Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.