Foundayo (orforglipron) vs CagriSema
Side-by-side comparison based on ATTAIN-1 and REDEFINE-1 phase 3 trial data plus April 2026 pricing.
Foundayo (orforglipron)
orforglipron (tablet)
Peak weight loss14.7%
TrialATTAIN-1
Administrationoral
FDA statuspending
List price$1,099/mo
CagriSema
Higher efficacycagrilintide + semaglutide
Peak weight loss20.4%
TrialREDEFINE-1
Administrationinjection
FDA statuspending
List price$1,499/mo
Weight loss comparison (220 lbs starting weight)
% of body weight lost over 18 months, modeled from phase 3 trial data
Monthly cost by payment channel
| Channel | Foundayo (orforglipron) | CagriSema | Difference |
|---|---|---|---|
| Covered by insurance ($25–150 copay) | $63 | $88 | $25 (Foundayo (orforglipron) cheaper) |
| Manufacturer self-pay (LillyDirect / NovoCare) | $499 | $599 | $100 (Foundayo (orforglipron) cheaper) |
| Telehealth — brand name (Hims, Ro, Found) | — | — | — |
| Cash retail (full list price) | $1,099 | $1,499 | $400 (Foundayo (orforglipron) cheaper) |
Foundayo (orforglipron) pros and cons
Pros
- ✓ Daily pill with NO fasting requirement (advantage over oral Wegovy)
- ✓ Non-peptide small molecule — easier manufacturing/scale
- ✓ 14.7% average weight loss in ATTAIN-1
- ✓ Likely to be lower-priced than peptide injections at scale
Cons
- ✗ Pending FDA approval (expected mid-2026)
- ✗ Less long-term safety data than older GLP-1s
- ✗ Daily adherence required
CagriSema pros and cons
Pros
- ✓ Highest efficacy of any pending GLP-1 (20.4% in REDEFINE-1)
- ✓ Dual mechanism (amylin + GLP-1) targets satiety differently
- ✓ Once-weekly injection like Wegovy
Cons
- ✗ Pending FDA approval (expected 2026)
- ✗ Combination therapy may carry premium pricing
- ✗ Limited long-term real-world data
Common side effects
Foundayo (orforglipron)
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
CagriSema
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
- • Decreased appetite
Which should you choose: Foundayo (orforglipron) or CagriSema?
Choose Foundayo (orforglipron) if: you prefer a daily pill over a weekly injection; cash-pay cost matters most to you.
Choose CagriSema if: you want maximum weight loss (20.4% vs 14.7%); you prefer a weekly injection over a daily pill.
Final decisions should always be made with a licensed prescriber. This is educational content only.
Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.