CagriSema (cagrilintide + semaglutide)
Combination therapy. NDA filed Dec 2025, FDA decision expected 2026. Manufactured by Novo Nordisk. FDA-approved status: pending.
Peak weight loss
20.4%
Trial
REDEFINE-1
Time to peak
68 wks
List price
$1,499/mo
CagriSema pricing across every channel
Manufacturer direct prices (LillyDirect, NovoCare) are usually cheapest. Updated April 2026.
| Drug | Insurance | Mfr direct | Telehealth (brand) | Telehealth (compd) | Cash retail | Get it |
|---|---|---|---|---|---|---|
| CagriSema 20.4% weight loss | $88 cheapest | $599 | — | — | $1,499 | N/A |
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CagriSema cost in 2026
| Payment channel | Monthly | 12 months |
|---|---|---|
| Covered by insurance ($25–150 copay) | $88 | $1,056 |
| Manufacturer self-pay (LillyDirect / NovoCare) | $599 | $7,188 |
| Telehealth — brand name (Hims, Ro, Found) | Not available | — |
| Telehealth — compounded (limited post-FDA crackdown) | Not available | — |
| Cash retail (full list price) | $1,499 | $17,988 |
Dosing
Weekly subcutaneous injection. Combines cagrilintide (amylin analog) with semaglutide.
What to expect on CagriSema
For someone starting at 220 lbs on CagriSema for 12 months, the projection is:
Expected loss at 12 mo
38.3 lbs
Final weight
181.7 lbs
Cost / lb lost
$470
Modeled from REDEFINE-1 phase 3 data. Adjust for your own weight on the full calculator.
✓ Pros
- Highest efficacy of any pending GLP-1 (20.4% in REDEFINE-1)
- Dual mechanism (amylin + GLP-1) targets satiety differently
- Once-weekly injection like Wegovy
✗ Cons
- Pending FDA approval (expected 2026)
- Combination therapy may carry premium pricing
- Limited long-term real-world data
Common side effects
Most-reported in REDEFINE-1. Side effects are typically worst during dose escalation and improve over time.
NauseaDiarrheaVomitingConstipationDecreased appetite
→ Full CagriSema side effects guide (timing, severity, when to call)Compare CagriSema to other GLP-1s
Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.